Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
disease ct 4 0.002 0.67 0.171 0.288
disease el 4 0.005 0.038 0.024 0.012
disease ka 4 0.0 0.688 0.178 0.295
disease rf 4 0.002 0.67 0.171 0.288
genetic_interaction el 8 0.009 0.885 0.459 0.321
genetic_interaction ka 8 0.041 0.197 0.132 0.051
genetic_interaction rf 8 0.016 0.88 0.454 0.317
phenotype ka 5 0.001 0.191 0.099 0.082

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 12 0.0 0.767 0.263 0.229
integration_mean_by_presence el 12 0.001 0.52 0.131 0.161
integration_mean_by_presence ka 12 0.0 0.503 0.175 0.16
integration_mean_by_presence rf 12 0.001 0.507 0.099 0.16
mean ct 12 0.0 0.581 0.248 0.205
mean el 12 0.0 0.496 0.142 0.173
mean ka 12 0.0 0.542 0.157 0.173
mean rf 12 0.0 0.518 0.099 0.162

CDF plots of non integrated kernels

CDF plots of integrated kernels